OmniPlex Neural Recording Data Acquisition System

OmniPlex® Neural Recording Data Acquisition System is Plexon’s flagship electrophysiology (a.k.a. ephys) research system. This system combines front-end amplification and acquisition with intuitive and powerful control and visualization software.

**OmniPlex Release 19 now available. Learn More about OmniPlex Release 19**

The OmniPlex System is a compact, flexible platform for high performance data acquisition and powerful online spike sorting. It offers low latency, superior common-mode rejection amplification and is well known for its user-friendliness. The OmniPlex System is a combination of the OmniPlex chassis, OmniPlex Software, and for new OmniPlex systems purchased today, a Digital Headstage Processor (DHP) subsystem – all described below. Other versions of the OmniPlex system could utilize an OmniAmp or DigiAmp A/D device.

  • The compact OmniPlex chassis is available in two sizes, Rack Mounted and Table Top, and houses cards for synchronization and timing between system components, acquisition subsystem links, digital inputs, and auxiliary analog inputs for non-neural experiment signals.
  • digital headstage processor for neural recording, omniplex, plexon, ephysThe OmniPlex System Controller operates the OmniPlex Software consisting of OmniPlex Server, the “software engine” for neural signal processing, and PlexControl, which is the main user interface providing data visualization and the user interface for interacting with the system.
  • The Digital Headstage Processor (DHP) for use with digital headstages is Plexon’s most advanced subsystem. The DHP now enables up to 512 channels of neural recording, decreased sensitivity to ambient electrical noise, and lighter headstage cables with fewer wires for greater freedom of animal movement. Further, it offers real-time upsampling to 40KHz and adjustment of multiplexer timing offsets (equivalent to simultaneous sampling) for improved sorting quality, trodal acquisition and software referencing – unlike other digital headstage based systems. Alternatively, the predecessor to the DHP is Plexon’s DigiAmp™ subsystem for analog headstages. The DigiAmp Digitizing Amplifier is available in two sizes: the MiniDigi™ for 16, 32, 48 and 64 channels, and the DigiAmp for 64, 128, 192 and 256 channels. This subsystem is recommended when using analog headstages. Both provide 16-bit A/D conversion at 40kHz per channel for acquisition of the complete wide-band signal. Flexible digital filtering supports a wide variety of filter types (Bessel, Butterworth, Elliptic, 2-12 poles, plus adaptive power line noise filter) and cutoff frequencies, for extracting spikes and field potentials from the wide-band signal and for noise removal.
  • The DHP and the DigiAmp digitizing amplifier are both electrically isolated.

Sorted spike and continuous data acquired by the OmniPlex System is available to external clients (developed through the C/C++ or MATLAB®software development kits (SDKs)) as soon as 1-2 milliseconds after acquisition. This figure is the actual end-to-end latency through the entire OmniPlex System from spike detection input to hardware output, including an online user client program.

The DigiAmps and all modules in the chassis are synchronized via a high-resolution master timing module. The same master timing module can be extended to synchronize timestamps with compatible equipment such as Plexon’s CinePlex® Behavioral Research System.

A Plexon Sales Engineer is happy to discuss your needs and how the OmniPlex could best support your ephys research goals.

OmniPlex System Features

Selected technical specifications for the OmniPlex System are provided below. A Plexon Sales Engineer is happy to discuss your needs and how the OmniPlex could best support your neural recording and ephys research goals.

FeaturesSpecifications and Options
– Digital Headstage Processor (DHP) subsystem
– DigiAmp™ Digitizing Amplifier subsystem
– DHP subsystem required for use with digital headstatges
– DigiAmp subsystem required for use with analog headstages
A/D input conversion40kHz per neural channel at 16-bit resolution– Simultaneous sampling
– Continuous wide-band recording
on all neural channels
25µsec (40kHz)
Filtering– Software selectable digital filtering
– 2-12 pole filters, Butterworth,
Bessel or Elliptic; notch filter
For isolation of field potential and spike frequency bands
ReferencingDigital selected channel referencing including:
– Common Average Referencing
(CAR) and
– Common Median Referencing
For online noise and artifact removal
Digital Inputsup to 64 channelsUp to four 16 channel ports, individual TTL and/or strobed word data
Auxiliary non-neural A/D inputs32 channels16 bit A/D conversion for auxiliary non-neural signals, 250kHz max rate (with “fast” card)
Trodal sorting supportStereotrode and tetrode
Channel mapping
User-definable mapping sets
Spike sortingAutomatic online in waveform space or directly in 2D/3D feature space– Waveform space includes
time/voltage using boxes,
templates, lines or bands
– Feature space includes PCA,
peak/valley and more
– Powerful graphical tools for
manually defining and adjusting
sorting parameters online
File type recorded
Plexon .PL2 and .PLX filesUtility provides conversion between formats
Compatibility– Plexon MATLAB®/C++ online and
offline SDKs
– PlexNet (TCP/IP or UDP), and
– NeuroExplorer® online link
Chassis dimensions (inches)Rack Mounted: 7 1/4 x 13 7/8 x 19 1/8

Table Top: 7 1/4 x 12 1/2 x 9 3/4

Manuals/User Guides

Includes features up to Release 18

Post date April 17, 2017

Installation Packages/Upgrades

Change Log

Guides and How To Papers

Analog version only

Technical Specs and Data Sheets

Analog version only


*Must use the OmniPlex Windows 10 Migration Guide in order to upgrade to Windows 10