CinePlex Behavioral Research System
The CinePlex® Behavioral Research System is possibly the industry’s most advanced approach to digital video recording, position tracking and behavioral analysis for freely moving and behaving animal experiments. Plexon’s CinePlex System is the only behavioral research system that can either be operated in full synchrony with neural data acquisition, or as a stand-alone solution.
**CinePlex Studio 3.11.0 now offers jitter elimination and more!**
CinePlex Behavioral Research System
For more than a decade, Plexon has developed, refined and expanded its leading video tracking and behavior analysis system – the CinePlex Behavioral Research System. The CinePlex System expertly transforms abstract activity into quantitative information able to be effectively examined and analyzed. It can be operated as a stand-alone solution in which the research does not require the simultaneous capture of neural signals. Alternatively, it can be operated in synchrony with OmniPlex® Neural Data Acquisition Systems or the Multichannel Acquisition Processor (MAP) Data Acquisition System.
The CinePlex System functions in all lighting conditions – light to dark – and is capable of operation online or offline with files. It is applicable to research with almost any maze or open field, and offers multiple tracking modes. The CinePlex System is capable of both two- and three-dimensional operation while supporting a choice of standard VGA or high definition cameras. It performs a wealth of statistical computations, and can export data to Excel®, MATLAB® or text files for further analysis.
A complete CinePlex System is a combination of specialized hardware and software customized to your research needs.
To observe the CinePlex System in use during a freely behaving rat experiment, we invite you to view the methods section within the publication “Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze” authored by a team in Rebecca Burwell’s Behavioral Neuroscience of Memory and Attention Lab at Brown University and published in the Journal of Visualized Experimentation (JoVE) on February 20, 2014. The study presented uses CinePlex Studio with the CinePlex Tracking and CinePlex Basic Behavior options, as well as the OmniPlex Neural Data Acquisition System for synchronized neural recording.
A Plexon Sales Engineer is available to provide additional information and to assist you in determining what CinePlex System configuration could best support your research most cost effectively.
The table below outlines selected information regarding the CinePlex System. For more information, see the CinePlex Software and individual application-specific pages – CinePlex Studio, CinePlex Editor, CinePlex Tracking, CinePlex Basic Behavior, and CinePlex 3D.
| Features | Specifications and Options | Remarks |
| Controller platform | Windows® 7 and 10 | Beginning with CinePlex Studio v3.9.0, only Windows 7 and 10 are supported. The last version to support Windows XP was CinePlex v3.5.0. |
| Software required for stand-alone operation | CinePlex Studio | |
| Software required for synchrony with neural data acquisition (NDAQ) | – CinePlex Studio and – CinePlex Editor | |
| Synchrony with NDAQ systems | – OmniPlex® and OmniPlex Systems – MAP Systems | Also synchronized with Tucker-Davis Technologies data acquisition systems, though with limited functionality. |
| Timing clock | 1MHz | Plexon’s OmniPlex, OmniPlex and MAP Systems use the same timing clock as does the CinePlex System. |
| Resolution of time stamps | 25µsec | |
| Video and neural file synchrony | Simultaneous starting, stopping, pausing and resuming of both files. | |
| Neural files saved to | Plexon (.PLX) and NeuroExplorer (.NEX) files | |
| Files read | MPEG and MJPEG files | |
| Video file format generated | Standard .AVI files in MPEG format | Essentially unlimited .AVI file size (Microsoft extension to NTFS format eliminates the 4GB size limit). |
| Video file compression | MPEG quality adjustable from 1 to 10. | CinePlex Studio default is 4. |
| Camera resolution and frames per second | – AVT Stingray: 640 x 480 resolution, 80fps – AVT Pike: 640 x 480 resolution, 200fps – AVT Pike: 960 x 960 high resolution, 60fps | All cameras are low noise. |
| Number of cameras supported | – AVT Stingray: 1 to 4 – AVT Pike (200fps): 1 to 4 | |
| Advanced functionality options | – CinePlex Tracking – CinePlex Basic Behavior – CinePlex 3D | 3 application-specific options are advanced functionality offered through CinePlex Studio, and available through licensing. |
| Integrated viewing of | Neural data files (Plexon .PLX, NeuroExplorer® .NEX) and .AVI files | |
| Export to | Excel®, MATLAB® or text files | |
| Licensing | Requires the purchase of a CinePlex System, plus a license key for each application-specific option. | All upgrades within a software version are free of charge and do not need a modification to the license key. Upgrades to the next version do require an updated key with expanded privileges. |
| Installation | The CinePlex Software can be loaded onto as many computers as you desire. However, the license key is required for operation. |
Any questions? Ask a Plexon Sales Engineer. We are happy to help.
- Manuals/User Guides
Post date December 2015
Post Date September 2018
Post date October 2014. This user guide contains updated functionality for the use of CinePlex integrated with OmniPlex only.
Legacy Manuals/User Guides
Post date February 2010. Comprehensive CinePlex User Guide through version 3.0.
Post date February 2008.
Installation Packages/Upgrades
Post date August 2021
Post date May 2014
Post date August 2014
Guides and How To Papers
- Camera Mounting Guide for CinePlex
- Integrating OmniPlex and CinePlex V3
- CinePlex Studio Windows 10 Migration Guide
Change Log
Technical Specs and Data Sheets
Research Articles with Video
Jacobson, Tara K., Jonathan W. Ho, Brendon W. Kent, Fang-Chi Yang, and Rebecca D. Burwell. “Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze.” JoVE (Journal of Visualized Experiments) 84 (2014): e51316-e51316.
2024
- Abbott, P. W., Hardie, J. B., Walsh, K. P., Nessler, A. J., Farley, S. J., Freeman, J. H., … Parker, K. L. (2024). Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact. The Cerebellum.
- Chang, L., Wang, C., Peng, J., Song, Y., Zhang, W., Chen, Y.-R., … Lan, Y. (2024). Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis. Journal of Agricultural and Food Chemistry.
2023
- Lantheaume, A., Schöneberg, N., Rodriguez-Rozada, S., Doll, D., Schellenberger, M., Kobel, K., Katzenberger, K., Signoret-Genest, J., Tissone, A. I., Ip, C. W., Esposito, M. S., & Tovote, P. (2023). A Viral Vector Model for Circuit-Specific Synucleinopathy.
- Signoret-Genest, Jérémy, Nina Schukraft, Sara L. Reis, Dennis Segebarth, Karl Deisseroth, and Philip Tovote. “Integrated Cardio-Behavioral Responses to Threat Define Defensive States.” Nature News. Nature Publishing Group
2022
- Alexander, Andrew S., Janet C. Tung, G. William Chapman, Allison M. Conner, Laura E. Shelley, Michael E. Hasselmo, and Douglas A. Nitz. Adaptive integration of self-motion and goals in posterior parietal cortex, March 8, 2022.
- Ning, W., Bladon, J. H., & Hasselmo, M. E. (n.d.). Complementary representations of time in the prefrontal cortex and hippocampus. July 13, 2022.
2021
- M;, Araragi N;Alenina N;Bader. “Carbon-Mixed Dental Cement for Fixing Fiber Optic Ferrules Prevents Visually Triggered Locomotive Enhancement in Mice upon Optogenetic Stimulation.” Heliyon. U.S. National Library of Medicine, 2021 Dec 21
- Lederman, James, Lardeux Sylvie, Nicola Saleem M. “Vigor Encoding in the Ventral Pallidum.” ENeuro, Society for Neuroscience, 1 July 2021.
- Liu, Honghao, Bo Li, Minjian Zhang, Chuankai Dai, Pengcheng Xi, Yafei Liu, Qiang Huang, Jiping He, Yiran Lang, and Rongyu Tang. “Unexpected Terrain Induced Changes in Cortical Activity in Bipedal-Walking Rats.” MDPI. Multidisciplinary Digital Publishing Institute, December 27, 2021.
- Manuel J. Ferreira-Pinto, Harsh Kanodia, Antonio Falasconi, Markus Sigrist, Maria S. Esposito, Silvia Arber, Functional diversity for body actions in the mesencephalic locomotor region,Cell, 2021 Aug 19.
2019
- Borkar CD, Dorofeikova M, Le QS, Vutukuri R, Vo C, Hereford D, Resendez A, Basavanhalli S, Sifnugel N, Fadok JP. Sex Differences in Behavioral Responses during a Conditioned Flight Paradigm. bioRxiv. 2019 Jan 1.
- Vincis R, Chen K, Czarnecki L, Chen J, Fontanini A. Dynamic representation of taste-related decisions in the gustatory insular cortex of mice. bioRxiv. 2019 Jan 1.
2018
- Arias-Cavieres A, Khuu MA, Nwakudu CU, Barnard JE, Dalgin G, Garcia AJ. A role for Hypoxia Inducible Factor 1a (HIF1a) in intermittent hypoxia-dependent changes in spatial memory and synaptic plasticity. bioRxiv. 2019 Jan 1:595975.
- Berger M, Gail A. The Reach Cage environment for wireless neural recordings during structured goal-directed behavior of unrestrained monkeys. 2018.
- Caref K, & Nicola SM. Endogenous opioids in the nucleus accumbens promote approach to high-fat food in the absence of caloric need. ELife,2018 Mar 27; 7.
- Chang E, Heskje J, Parker KL. Developmental characterization of motor impairments in mice with spinocerebellar ataxia1. Trial.;1(2):3.
- Gründemann J, Bitterman Y, Lu T, Krabbe S, Grewe BF, Schnitzer MJ, Lüthi A. Amygdala neuronal ensembles dynamically encode behavioral states. bioRxiv. 2018 Jan 1:425736.
- Kinsky NR, Mau W, Sullivan DW, Levy SJ, Ruesch EA, Hasselmo ME. Hippocampal Neuron Functional Phenotype Influences the Stability of Its Neural Code. bioRxiv. 2019 Jan 1:676593.
- Laurens J, Abrego A, Cham H, Popeney B, Yu Y, Rotem N, Aarse J, Dickman D, Angelaki D. Multiplexed code of navigation variables in the anterior limbic system. bioRxiv. 2019 Jan 1:684464.
- Li M, Xie K, Kuang H, Liu J, Wang D, Fox GE, Shi Z, Chen L, Zhao F, Mao Y, & Tsien JZ. Neural Coding of Cell Assemblies via Spike-Timing Self-Information. Cerebral Cortex,2018 July 1; 28(7), 2563-2576.
- Liu LY, Zang RL, Chen L, Zhao HY, Cai J, Wang JK, Guo DQ, Cui YJ, Xing GG. Chronic stress increases pain sensitivity via activation of the rACC–BLA pathway in rats. Experimental Neurology. 2018 Dec 23.
- Stoppel LJ, Kazdoba TM, Schaffler MD, Preza AR, Heynen A, Crawley JN, & Bear MF. R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice. Neuropsychopharmacology, 2018; 43, 513–524.
- Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Molecular Psychiatry. 2018 Nov 9:1.
2017
- Freeman DK, O’Brien JM, Kumar P, Daniels B, Irion RA, Shraytah L, Ingersoll BK, Magyar AP, Czarnecki A, Wheeler J, Coppeta JR. A Sub-millimeter, Inductively Powered Neural Stimulator. Frontiers in neuroscience. 2017 Nov 27;11:659.
- Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K. Sevoflurane induces coherent slow-delta oscillations in rats. Frontiers in neural circuits. 2017 Jul 4;11:36.
- Li Q, Ko H, Qian ZM, Yan LY, Chan DC, Arbuthnott G, Ke Y, Yung WH. Refinement of learned skilled movement representation in motor cortex deep output layer. Nature communications. 2017 Jun 9;8:15834.
2016
- Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. Elife. 2016;5.
- Keene CS, Bladon J, McKenzie S, Liu CD, O’Keefe J, Eichenbaum H. Complementary functional organization of neuronal activity patterns in the perirhinal, lateral entorhinal, and medial entorhinal cortices. Journal of Neuroscience. 2016 Mar 30;36(13):3660-75.
- Marcinkiewcz CA, Mazzone CM, D’Agostino G, Halladay LR, Hardaway JA, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton GJ. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature. 2016 Sep;537(7618):97.
- Omrani M, Murnaghan CD, Pruszynski JA, Scott SH. Distributed task-specific processing of somatosensory feedback for voluntary motor control. Elife. 2016;5.
- Place R, Farovik A, Brockmann M, Eichenbaum H. Bidirectional prefrontal-hippocampal interactions support context-guided memory. Nature neuroscience. 2016 Aug;19(8):992.
- Tang Y, Benusiglio D, Grinevich V, Lin L. Distinct Types of Feeding Related Neurons in Mouse Hypothalamus. Frontiers in behavioral neuroscience. 2016 May 18;10:91.
- Xie K, Fox GE, Liu J, Tsien JZ. 512-Channel and 13-region simultaneous recordings coupled with optogenetic manipulation in freely behaving mice. Frontiers in systems neuroscience. 2016 Jun 14;10:48.
- Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ. A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses. Molecular psychiatry. 2016 Sep 27.
2015
- Cooke SF, Komorowski RW, Kaplan ES, Gavornik JP, Bear MF. Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1. Nature neuroscience. 2015 Feb;18(2):262.
- Farovik A, Place RJ, McKenzie S, Porter B, Munro CE, Eichenbaum H. Orbitofrontal cortex encodes memories within value-based schemas and represents contexts that guide memory retrieval. Journal of Neuroscience. 2015 May 27;35(21):8333-44.
- Lee RX, Huang JJ, Huang C, Tsai ML, Yen CT. Plasticity of cerebellar Purkinje cells in behavioral training of body balance control. Frontiers in systems neuroscience. 2015 Aug 5;9:113.
- Tingley D, Alexander AS, Quinn LK, Chiba AA, Nitz DA. Cell assemblies of the basal forebrain. Journal of Neuroscience. 2015 Feb 18;35(7):2992-3000.
2014
- Desai VH, Anand S, Tran M, Kanneganti A, Vasudevan S, Seifert JL, Cheng J, Keefer EW, Romero-Ortega MI. Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces. InEngineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE 2014 Aug 26 (pp. 1973-1976). IEEE.
- Liu J, Wei W, Kuang H, Tsien JZ, Zhao F. Heart rate and heart rate variability assessment identifies individual differences in fear response magnitudes to earthquake, free fall, and air puff in mice. PLoS One. 2014 Mar 25;9(3):e93270.
- Ognjanovski N, Maruyama D, Lashner N, Zochowski M, Aton SJ. CA1 hippocampal network activity changes during sleep-dependent memory consolidation. Frontiers in systems neuroscience. 2014 Apr 17;8:61.
- Sankaranarayani R, Raghavan M, Nalini A, Laxmi TR, Raju TR. Reach task-associated excitatory overdrive of motor cortical neurons following infusion with ALS-CSF. Journal of Neural Transmission. 2014 Jan 1;121(1):49-58.
2013
2012
- Febo M. Firing patterns of maternal rat prelimbic neurons during spontaneous contact with pups. Brain research bulletin. 2012 Aug 1;88(5):534-42.
- Yanagihara S, Hessler NA. Phasic basal ganglia activity associated with high-gamma oscillation during sleep in a songbird. Journal of neurophysiology. 2012 Jan 1;107(1):424-32.\
- Matsumoto J, Urakawa S, Hori E, de Araujo MF, Sakuma Y, Ono T, Nishijo H. Neuronal responses in the nucleus accumbens shell during sexual behavior in male rats. Journal of Neuroscience. 2012 Feb 1;32(5):1672-86.
2011
- Febo M. Prefrontal cell firing in male rats during approach towards sexually receptive female: interactions with cocaine. Synapse. 2011 Apr 1;65(4):271-7.
- MacDonald CJ, Lepage KQ, Eden UT, Eichenbaum H. Hippocampal “time cells” bridge the gap in memory for discontiguous events. Neuron. 2011 Aug 25;71(4):737-49
- Tseng WT, Yen CT, Tsai ML. A bundled microwire array for long-term chronic single-unit recording in deep brain regions of behaving rats. Journal of neuroscience methods. 2011 Oct 15;201(2):368-76.
- Wang DV, Tsien JZ. Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population. PLoS One. 2011 Jan 27;6(1):e16528.
- Wang DV, Tsien JZ. Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations. PloS one. 2011 Feb 15;6(2):e17047.
- Wang LP, Li F, Wang D, Xie K, Wang D, Shen X, Tsien JZ. NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron. 2011 Dec 22;72(6):1055-66.
2010
2009
For more than a decade, Plexon has developed, refined and expanded its leading video tracking and behavior analysis system – the CinePlex Behavioral Research System. The CinePlex System expertly transforms abstract activity into quantitative information able to be effectively examined and analyzed. It can be operated as a stand-alone solution in which the research does not require the simultaneous capture of neural signals. Alternatively, it can be operated in synchrony with OmniPlex® Neural Data Acquisition Systems or the Multichannel Acquisition Processor (MAP) Data Acquisition System.
The CinePlex System functions in all lighting conditions – light to dark – and is capable of operation online or offline with files. It is applicable to research with almost any maze or open field, and offers multiple tracking modes. The CinePlex System is capable of both two- and three-dimensional operation while supporting a choice of standard VGA or high definition cameras. It performs a wealth of statistical computations, and can export data to Excel®, MATLAB® or text files for further analysis.
A complete CinePlex System is a combination of specialized hardware and software customized to your research needs.
To observe the CinePlex System in use during a freely behaving rat experiment, we invite you to view the methods section within the publication “Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze” authored by a team in Rebecca Burwell’s Behavioral Neuroscience of Memory and Attention Lab at Brown University and published in the Journal of Visualized Experimentation (JoVE) on February 20, 2014. The study presented uses CinePlex Studio with the CinePlex Tracking and CinePlex Basic Behavior options, as well as the OmniPlex Neural Data Acquisition System for synchronized neural recording.
A Plexon Sales Engineer is available to provide additional information and to assist you in determining what CinePlex System configuration could best support your research most cost effectively.
The table below outlines selected information regarding the CinePlex System. For more information, see the CinePlex Software and individual application-specific pages – CinePlex Studio, CinePlex Editor, CinePlex Tracking, CinePlex Basic Behavior, and CinePlex 3D.
| Features | Specifications and Options | Remarks |
| Controller platform | Windows® 7 and 10 | Beginning with CinePlex Studio v3.9.0, only Windows 7 and 10 are supported. The last version to support Windows XP was CinePlex v3.5.0. |
| Software required for stand-alone operation | CinePlex Studio | |
| Software required for synchrony with neural data acquisition (NDAQ) | – CinePlex Studio and – CinePlex Editor | |
| Synchrony with NDAQ systems | – OmniPlex® and OmniPlex Systems – MAP Systems | Also synchronized with Tucker-Davis Technologies data acquisition systems, though with limited functionality. |
| Timing clock | 1MHz | Plexon’s OmniPlex, OmniPlex and MAP Systems use the same timing clock as does the CinePlex System. |
| Resolution of time stamps | 25µsec | |
| Video and neural file synchrony | Simultaneous starting, stopping, pausing and resuming of both files. | |
| Neural files saved to | Plexon (.PLX) and NeuroExplorer (.NEX) files | |
| Files read | MPEG and MJPEG files | |
| Video file format generated | Standard .AVI files in MPEG format | Essentially unlimited .AVI file size (Microsoft extension to NTFS format eliminates the 4GB size limit). |
| Video file compression | MPEG quality adjustable from 1 to 10. | CinePlex Studio default is 4. |
| Camera resolution and frames per second | – AVT Stingray: 640 x 480 resolution, 80fps – AVT Pike: 640 x 480 resolution, 200fps – AVT Pike: 960 x 960 high resolution, 60fps | All cameras are low noise. |
| Number of cameras supported | – AVT Stingray: 1 to 4 – AVT Pike (200fps): 1 to 4 | |
| Advanced functionality options | – CinePlex Tracking – CinePlex Basic Behavior – CinePlex 3D | 3 application-specific options are advanced functionality offered through CinePlex Studio, and available through licensing. |
| Integrated viewing of | Neural data files (Plexon .PLX, NeuroExplorer® .NEX) and .AVI files | |
| Export to | Excel®, MATLAB® or text files | |
| Licensing | Requires the purchase of a CinePlex System, plus a license key for each application-specific option. | All upgrades within a software version are free of charge and do not need a modification to the license key. Upgrades to the next version do require an updated key with expanded privileges. |
| Installation | The CinePlex Software can be loaded onto as many computers as you desire. However, the license key is required for operation. |
Any questions? Ask a Plexon Sales Engineer. We are happy to help.
- Manuals/User Guides
Post date December 2015
Post Date September 2018
Post date October 2014. This user guide contains updated functionality for the use of CinePlex integrated with OmniPlex only.
Legacy Manuals/User Guides
Post date February 2010. Comprehensive CinePlex User Guide through version 3.0.
Post date February 2008.
Installation Packages/Upgrades
Post date November 2021
Post date May 2014
Post date August 2014
Guides and How To Papers
- Camera Mounting Guide for CinePlex
- Integrating OmniPlex and CinePlex V3
- CinePlex Studio Windows 10 Migration Guide
Change Log
Technical Specs and Data Sheets
Research Articles with Video
Jacobson, Tara K., Jonathan W. Ho, Brendon W. Kent, Fang-Chi Yang, and Rebecca D. Burwell. “Automated Visual Cognitive Tasks for Recording Neural Activity Using a Floor Projection Maze.” JoVE (Journal of Visualized Experiments) 84 (2014): e51316-e51316.
2024
- Abbott, P. W., Hardie, J. B., Walsh, K. P., Nessler, A. J., Farley, S. J., Freeman, J. H., … Parker, K. L. (2024). Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact. The Cerebellum.
- Chang, L., Wang, C., Peng, J., Song, Y., Zhang, W., Chen, Y.-R., … Lan, Y. (2024). Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis. Journal of Agricultural and Food Chemistry.
2023
- Lantheaume, A., Schöneberg, N., Rodriguez-Rozada, S., Doll, D., Schellenberger, M., Kobel, K., Katzenberger, K., Signoret-Genest, J., Tissone, A. I., Ip, C. W., Esposito, M. S., & Tovote, P. (2023). A Viral Vector Model for Circuit-Specific Synucleinopathy.
- Signoret-Genest, Jérémy, Nina Schukraft, Sara L. Reis, Dennis Segebarth, Karl Deisseroth, and Philip Tovote. “Integrated Cardio-Behavioral Responses to Threat Define Defensive States.” Nature News. Nature Publishing Group
2022
- Alexander, Andrew S., Janet C. Tung, G. William Chapman, Allison M. Conner, Laura E. Shelley, Michael E. Hasselmo, and Douglas A. Nitz. Adaptive integration of self-motion and goals in posterior parietal cortex, March 8, 2022.
- Ning, W., Bladon, J. H., & Hasselmo, M. E. (n.d.). Complementary representations of time in the prefrontal cortex and hippocampus. July 13, 2022.
2021
- Lederman, James, Lardeux Sylvie, Nicola Saleem M. “Vigor Encoding in the Ventral Pallidum.” ENeuro, Society for Neuroscience, 1 July 2021.
- Manuel J. Ferreira-Pinto, Harsh Kanodia, Antonio Falasconi, Markus Sigrist, Maria S. Esposito, Silvia Arber, Functional diversity for body actions in the mesencephalic locomotor region,Cell, 2021 Aug 19.
2019
- Borkar CD, Dorofeikova M, Le QS, Vutukuri R, Vo C, Hereford D, Resendez A, Basavanhalli S, Sifnugel N, Fadok JP. Sex Differences in Behavioral Responses during a Conditioned Flight Paradigm. bioRxiv. 2019 Jan 1.
- Vincis R, Chen K, Czarnecki L, Chen J, Fontanini A. Dynamic representation of taste-related decisions in the gustatory insular cortex of mice. bioRxiv. 2019 Jan 1.
2018
- Arias-Cavieres A, Khuu MA, Nwakudu CU, Barnard JE, Dalgin G, Garcia AJ. A role for Hypoxia Inducible Factor 1a (HIF1a) in intermittent hypoxia-dependent changes in spatial memory and synaptic plasticity. bioRxiv. 2019 Jan 1:595975.
- Berger M, Gail A. The Reach Cage environment for wireless neural recordings during structured goal-directed behavior of unrestrained monkeys. 2018.
- Caref K, & Nicola SM. Endogenous opioids in the nucleus accumbens promote approach to high-fat food in the absence of caloric need. ELife,2018 Mar 27; 7.
- Chang E, Heskje J, Parker KL. Developmental characterization of motor impairments in mice with spinocerebellar ataxia1. Trial.;1(2):3.
- Gründemann J, Bitterman Y, Lu T, Krabbe S, Grewe BF, Schnitzer MJ, Lüthi A. Amygdala neuronal ensembles dynamically encode behavioral states. bioRxiv. 2018 Jan 1:425736.
- Kinsky NR, Mau W, Sullivan DW, Levy SJ, Ruesch EA, Hasselmo ME. Hippocampal Neuron Functional Phenotype Influences the Stability of Its Neural Code. bioRxiv. 2019 Jan 1:676593.
- Laurens J, Abrego A, Cham H, Popeney B, Yu Y, Rotem N, Aarse J, Dickman D, Angelaki D. Multiplexed code of navigation variables in the anterior limbic system. bioRxiv. 2019 Jan 1:684464.
- Li M, Xie K, Kuang H, Liu J, Wang D, Fox GE, Shi Z, Chen L, Zhao F, Mao Y, & Tsien JZ. Neural Coding of Cell Assemblies via Spike-Timing Self-Information. Cerebral Cortex,2018 July 1; 28(7), 2563-2576.
- Liu LY, Zang RL, Chen L, Zhao HY, Cai J, Wang JK, Guo DQ, Cui YJ, Xing GG. Chronic stress increases pain sensitivity via activation of the rACC–BLA pathway in rats. Experimental Neurology. 2018 Dec 23.
- Stoppel LJ, Kazdoba TM, Schaffler MD, Preza AR, Heynen A, Crawley JN, & Bear MF. R-Baclofen Reverses Cognitive Deficits and Improves Social Interactions in Two Lines of 16p11.2 Deletion Mice. Neuropsychopharmacology, 2018; 43, 513–524.
- Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Molecular Psychiatry. 2018 Nov 9:1.
2017
- Freeman DK, O'Brien JM, Kumar P, Daniels B, Irion RA, Shraytah L, Ingersoll BK, Magyar AP, Czarnecki A, Wheeler J, Coppeta JR. A Sub-millimeter, Inductively Powered Neural Stimulator. Frontiers in neuroscience. 2017 Nov 27;11:659.
- Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K. Sevoflurane induces coherent slow-delta oscillations in rats. Frontiers in neural circuits. 2017 Jul 4;11:36.
- Li Q, Ko H, Qian ZM, Yan LY, Chan DC, Arbuthnott G, Ke Y, Yung WH. Refinement of learned skilled movement representation in motor cortex deep output layer. Nature communications. 2017 Jun 9;8:15834.
2016
- Gamble-George JC, Baldi R, Halladay L, Kocharian A, Hartley N, Silva CG, Roberts H, Haymer A, Marnett LJ, Holmes A, Patel S. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. Elife. 2016;5.
- Keene CS, Bladon J, McKenzie S, Liu CD, O'Keefe J, Eichenbaum H. Complementary functional organization of neuronal activity patterns in the perirhinal, lateral entorhinal, and medial entorhinal cortices. Journal of Neuroscience. 2016 Mar 30;36(13):3660-75.
- Marcinkiewcz CA, Mazzone CM, D’Agostino G, Halladay LR, Hardaway JA, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton GJ. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature. 2016 Sep;537(7618):97.
- Omrani M, Murnaghan CD, Pruszynski JA, Scott SH. Distributed task-specific processing of somatosensory feedback for voluntary motor control. Elife. 2016;5.
- Place R, Farovik A, Brockmann M, Eichenbaum H. Bidirectional prefrontal-hippocampal interactions support context-guided memory. Nature neuroscience. 2016 Aug;19(8):992.
- Tang Y, Benusiglio D, Grinevich V, Lin L. Distinct Types of Feeding Related Neurons in Mouse Hypothalamus. Frontiers in behavioral neuroscience. 2016 May 18;10:91.
- Xie K, Fox GE, Liu J, Tsien JZ. 512-Channel and 13-region simultaneous recordings coupled with optogenetic manipulation in freely behaving mice. Frontiers in systems neuroscience. 2016 Jun 14;10:48.
- Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ. A novel mechanism of memory loss in Alzheimer’s disease mice via the degeneration of entorhinal–CA1 synapses. Molecular psychiatry. 2016 Sep 27.
2015
- Cooke SF, Komorowski RW, Kaplan ES, Gavornik JP, Bear MF. Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1. Nature neuroscience. 2015 Feb;18(2):262.
- Farovik A, Place RJ, McKenzie S, Porter B, Munro CE, Eichenbaum H. Orbitofrontal cortex encodes memories within value-based schemas and represents contexts that guide memory retrieval. Journal of Neuroscience. 2015 May 27;35(21):8333-44.
- Lee RX, Huang JJ, Huang C, Tsai ML, Yen CT. Plasticity of cerebellar Purkinje cells in behavioral training of body balance control. Frontiers in systems neuroscience. 2015 Aug 5;9:113.
- Tingley D, Alexander AS, Quinn LK, Chiba AA, Nitz DA. Cell assemblies of the basal forebrain. Journal of Neuroscience. 2015 Feb 18;35(7):2992-3000.
2014
- Desai VH, Anand S, Tran M, Kanneganti A, Vasudevan S, Seifert JL, Cheng J, Keefer EW, Romero-Ortega MI. Chronic sensory-motor activity in behaving animals using regenerative multi-electrode interfaces. InEngineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE 2014 Aug 26 (pp. 1973-1976). IEEE.
- Liu J, Wei W, Kuang H, Tsien JZ, Zhao F. Heart rate and heart rate variability assessment identifies individual differences in fear response magnitudes to earthquake, free fall, and air puff in mice. PLoS One. 2014 Mar 25;9(3):e93270.
- Ognjanovski N, Maruyama D, Lashner N, Zochowski M, Aton SJ. CA1 hippocampal network activity changes during sleep-dependent memory consolidation. Frontiers in systems neuroscience. 2014 Apr 17;8:61.
- Sankaranarayani R, Raghavan M, Nalini A, Laxmi TR, Raju TR. Reach task-associated excitatory overdrive of motor cortical neurons following infusion with ALS-CSF. Journal of Neural Transmission. 2014 Jan 1;121(1):49-58.
2013
2012
- Febo M. Firing patterns of maternal rat prelimbic neurons during spontaneous contact with pups. Brain research bulletin. 2012 Aug 1;88(5):534-42.
- Yanagihara S, Hessler NA. Phasic basal ganglia activity associated with high-gamma oscillation during sleep in a songbird. Journal of neurophysiology. 2012 Jan 1;107(1):424-32.\
- Matsumoto J, Urakawa S, Hori E, de Araujo MF, Sakuma Y, Ono T, Nishijo H. Neuronal responses in the nucleus accumbens shell during sexual behavior in male rats. Journal of Neuroscience. 2012 Feb 1;32(5):1672-86.
2011
- Febo M. Prefrontal cell firing in male rats during approach towards sexually receptive female: interactions with cocaine. Synapse. 2011 Apr 1;65(4):271-7.
- MacDonald CJ, Lepage KQ, Eden UT, Eichenbaum H. Hippocampal “time cells” bridge the gap in memory for discontiguous events. Neuron. 2011 Aug 25;71(4):737-49
- Tseng WT, Yen CT, Tsai ML. A bundled microwire array for long-term chronic single-unit recording in deep brain regions of behaving rats. Journal of neuroscience methods. 2011 Oct 15;201(2):368-76.
- Wang DV, Tsien JZ. Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population. PLoS One. 2011 Jan 27;6(1):e16528.
- Wang DV, Tsien JZ. Convergent processing of both positive and negative motivational signals by the VTA dopamine neuronal populations. PloS one. 2011 Feb 15;6(2):e17047.
- Wang LP, Li F, Wang D, Xie K, Wang D, Shen X, Tsien JZ. NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron. 2011 Dec 22;72(6):1055-66.
2010
2009
The CinePlex System is powered by two primary programs–CinePlex Studio and CinePlex Editor. Together, they are referred to as the CinePlex Software. All users of the CinePlex Behavioral Research System will require CinePlex Studio, while only those using the CinePlex System in conjunction with either the OmniPlex® Neural Data Acquisition Systems or the Multichannel Acquisition Processor (MAP) Data Acquisition System will require the CinePlex Editor software.
When behavioral research requires data capture and manipulation beyond specialized recording capabilities, CinePlex Studio can be unlocked to leverage advanced features through application-specific options:
- CinePlex Tracking offers arena definition and powerful automated tracking of time and positioning data via multiple tracking modes – both online and offline.
- CinePlex Basic Behavior enables the further breakdown of arenas into various logically-interrelated zones, the generation of simple and complex digital events in response to activity within the zones, and the automatic calculation of real-time statistics.
- CinePlex 3D makes possible the recording and tracking of color markers from two or more simultaneous video streams in three dimensions – all with a remarkably simple system and camera calibration, freeing the researcher from a fixed recording environment.
CinePlex Studio is designed in a modular fashion for maximum flexibility and cost-effectiveness. Researchers can minimize costs, choosing only what options, if any, are valuable to their research. All upgrades within a version are free of charge and will be bundled into a single CinePlex Software upgrade package accessible online upon release.
CinePlex Studio
CinePlex Studio is the robust data acquisition portion of the CinePlex System providing the ability to capture video to .AVI files for online or later (offline) viewing and analysis.
CinePlex Studio features:
- Triggered video capture for more accurate time stamping of video frames
- Multi-camera support at up to 200 frames per second
- Flexibility to record in normal light, or via near infrared if the experimental conditions require a dark environment.
While CinePlex Studio provides the core of the behavioral research system functionality, CinePlex Editor provides the ability to manipulate behavioral data in relation to neural data. Together, both programs comprise the CinePlex Software.
CinePlex Editor is an integrated video and neural data file playback program with editing functionality that enables the OmniPlex® Neural Data Acquisition System or Multichannel Acquisition Processor (MAP) Data Acquisition System user to view and edit synchronized video and neural data files together.
CinePlex Editor offers:
- Full digital recorder (DVR) playback capabilities
- Visualization of position data (if utilizing CinePlex Tracking) overlaid on the video image.
- Sophisticated algorithms for event marker-based searching functionality for rapid data review
- User-defined audio cues that can be triggered when event markers or neural spikes occur during payback.
Behavioral Research Hardware
- CinePlex Controller: a powerful computer capable of processing the large video files while simultaneously running all associated programs including the CinePlex Software, as well as optional data acquisition programs (OmniPlex Software or MAP Software).
- Cameras: low-noise, standard VGA or high definition FireWire cameras. The CinePlex System is capable of supporting from one to four cameras depending on the configuration chosen.
- CinePlex Interface Module: provides camera triggers, Nth frame pulses and recording status to external equipment; utilized in stand-alone operation only.
- Accessories: including calibration grids, assorted cables, and computer peripherals such as a monitor, keyboard, mouse, etc. The CinePlex System is remarkably flexible and can be configured to meet your research requirements and budget. Much of the functionality is within the software and can be expanded when and if necessary.
The CinePlex System is powered by two primary programs–CinePlex Studio and CinePlex Editor. Together, they are referred to as the CinePlex Software. All users of the CinePlex Behavioral Research System will require CinePlex Studio, while only those using the CinePlex System in conjunction with either the OmniPlex® Neural Data Acquisition Systems or the Multichannel Acquisition Processor (MAP) Data Acquisition System will require the CinePlex Editor software.
When behavioral research requires data capture and manipulation beyond specialized recording capabilities, CinePlex Studio can be unlocked to leverage advanced features through application-specific options:
- CinePlex Tracking offers arena definition and powerful automated tracking of time and positioning data via multiple tracking modes – both online and offline.
- CinePlex Basic Behavior enables the further breakdown of arenas into various logically-interrelated zones, the generation of simple and complex digital events in response to activity within the zones, and the automatic calculation of real-time statistics.
- CinePlex 3D makes possible the recording and tracking of color markers from two or more simultaneous video streams in three dimensions – all with a remarkably simple system and camera calibration, freeing the researcher from a fixed recording environment.
CinePlex Studio is designed in a modular fashion for maximum flexibility and cost-effectiveness. Researchers can minimize costs, choosing only what options, if any, are valuable to their research. All upgrades within a version are free of charge and will be bundled into a single CinePlex Software upgrade package accessible online upon release.
CinePlex Studio
CinePlex Studio is the robust data acquisition portion of the CinePlex System providing the ability to capture video to .AVI files for online or later (offline) viewing and analysis.
CinePlex Studio features:
- Triggered video capture for more accurate time stamping of video frames
- Multi-camera support at up to 200 frames per second
- Flexibility to record in normal light, or via near infrared if the experimental conditions require a dark environment.
While CinePlex Studio provides the core of the behavioral research system functionality, CinePlex Editor provides the ability to manipulate behavioral data in relation to neural data. Together, both programs comprise the CinePlex Software.
CinePlex Editor is an integrated video and neural data file playback program with editing functionality that enables the OmniPlex® Neural Data Acquisition System or Multichannel Acquisition Processor (MAP) Data Acquisition System user to view and edit synchronized video and neural data files together.
CinePlex Editor offers:
- Full digital recorder (DVR) playback capabilities
- Visualization of position data (if utilizing CinePlex Tracking) overlaid on the video image.
- Sophisticated algorithms for event marker-based searching functionality for rapid data review
- User-defined audio cues that can be triggered when event markers or neural spikes occur during payback.
Behavioral Research Hardware
- CinePlex Controller: a powerful computer capable of processing the large video files while simultaneously running all associated programs including the CinePlex Software, as well as optional data acquisition programs (OmniPlex Software or MAP Software).
- Cameras: low-noise, standard VGA or high definition FireWire cameras. The CinePlex System is capable of supporting from one to four cameras depending on the configuration chosen.
- CinePlex Interface Module: provides camera triggers, Nth frame pulses and recording status to external equipment; utilized in stand-alone operation only.
- Accessories: including calibration grids, assorted cables, and computer peripherals such as a monitor, keyboard, mouse, etc. The CinePlex System is remarkably flexible and can be configured to meet your research requirements and budget. Much of the functionality is within the software and can be expanded when and if necessary.
Behavioral Tracking Videos
Y Maze
T Maze
Water Maze
Rat on Treadmill
Head Direction Event
3D Monkey Tracking
Tracking Videos
Y Maze
T Maze
Water Maze
Rat on Treadmill
Head Direction Event
3D Monkey Tracking
Integrate with Electrophysiology
Seamlessly integrate behavioral tracking with our OmniPlex Neural Recording System to create time-locked events in the recording data. Additionally, incorporating the Carousel commutator makes it possible to record neural activity and optogenetically stimulate in awake and freely moving animals.
Integrate with Electrophysiology
Seamlessly integrate behavioral tracking with our OmniPlex Neural Recording System to create time-locked events in the recording data. Additionally, incorporating the Carousel commutator makes it possible to record neural activity and optogenetically stimulate in awake and freely moving animals.