OmniPlex Neural Recording Data Acquisition System
Plexon Systems · Flagship Electrophysiology

OmniPlex Neural Recording Data Acquisition System

Plexon's flagship ephys research system, combining front-end amplification and acquisition with intuitive, powerful control and visualization software.

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512
Channels
40kHz
Per-Channel Sampling
1–2ms
End-to-End Latency

The OmniPlex System is a compact, flexible platform for high performance data acquisition and powerful online spike sorting, combining low latency, superior common-mode rejection amplification, and an intuitive interface across three core parts.

OmniPlex Chassis

Rack Mounted or Table Top, timing, and I/O for the whole system.

OmniPlex Software

OmniPlex Server handles signal processing; PlexControl is the visualization and control interface.

Digital Headstage Processor

Up to 512 channels, real-time 40kHz sampling, lighter cables, lower noise.

Compatibility

MATLAB®/C++ SDKs, Python SDK, PlexNet protocol, and NeuroExplorer® online link.

Isolation & Placement

The DHP is electrically isolated, and can sit up to 25 feet from the chassis.

Data Latency

Sorted and continuous data reach external SDKs in as little as 1–2 milliseconds.

All modules sync via a high-resolution master timing module, extendable to Plexon's CinePlex® system. Learn more about the online spike sorting software, or talk to a Plexon Sales Engineer about your research goals.

Selected technical specifications for the OmniPlex System are provided below. A Plexon Sales Engineer is happy to discuss your needs and how the OmniPlex could best support your neural recording and ephys research goals.

FeaturesSpecifications and OptionsRemarks
SubsystemsDigital Headstage Processor (DHP) acquisition subsystemRequired for use with digital headstages
A/D input conversion40kHz per neural channel at 16-bit resolution– Continuous wide-band recording on all neural channels
Timestamping25µsec (40kHz)
Filtering– Software selectable digital filtering
– 2-12 pole filters, Butterworth, Bessel or Elliptic		For isolation of field potential and spike frequency bands
ReferencingDigital selected channel referencing including:
– Common Average Referencing (CAR)
– Common Median Referencing (CMR)		For online noise and artifact removal
Digital InputsUp to 64 channelsUp to four 16 channel ports, individual TTL and/or strobed word data
Auxiliary non-neural A/D inputs32 channels16 bit A/D conversion for auxiliary non-neural signals, 250kHz max rate (with "fast" card)
Trodal sorting supportStereotrode and tetrode
Channel mappingUser-definable mapping sets
Spike sortingAutomatic online in waveform space or directly in 2D/3D feature space– Waveform space includes time/voltage using boxes, templates, lines or bands
– Feature space includes PCA, peak/valley and more
– Powerful graphical tools for manually defining and adjusting sorting parameters online
File type recordedPlexon .PL2 and .PLX filesUtility provides conversion between formats
Compatibility– Plexon MATLAB®/C++ online and offline SDKs
– Python SDK
– PlexNet (TCP/IP or UDP)
– NeuroExplorer® online link
Chassis dimensions (inches)Rack Mounted: 7 1/4 x 13 7/8 x 19 1/8
Table Top: 7 1/4 x 12 1/2 x 9 3/4

PlexControl

PlexControl software

PlexControl is the online spike sorting software for the OmniPlex System, with a flexible, customizable interface for signal visualization and spike waveform classification. It supports box, template, line, and band sorting in time/voltage space, plus contour sorting in PCA feature space, for single electrodes, stereotrodes, and tetrodes.

Spike, field potential, and wide-band signals display together with 2D/3D feature-space clusters for online sorting. All signal types, plus thresholded waveforms and digital events, can be recorded to disk per channel.

Highlighted Features

OmniPlex Server

The OmniPlex Server is the engine under PlexControl. It acquires data from the chassis and amplifiers, sends commands to hardware, and runs the digital signal processing for filtering, spike detection, and sorting, built on a modular dataflow topology with a setup wizard for custom configurations.

It's compatible with Plexon's MATLAB® and C/C++ SDKs and the NeuroExplorer® online link for closed-loop experiments, plus the PlexNet protocol for remote data access and PlexUtil for modifying output files.

OmniPlex Software arrives pre-loaded with every OmniPlex System. A Plexon Sales Engineer is happy to answer any questions.

FeaturesSpecifications and OptionsRemarks
Recording file formatsPlexon (.PL2, .PLX)
Spike detection methodsVoltage threshold
Spike sorting methods– Manual methods include: template, line sorting, band sorting, box sorting, 2-D polygon sorting
– Automatic methods include: template, band sorting, 2-D polygon sorting
Features available for sorting– Projections onto principal components (PCA)
– For stereotrode and tetrode data, per-electrode features
Views availableWideband continuous, spike continuous, field potentials, spike waveforms, 2D/3D PCA clusters, stereotrode and tetrode features, spike activity, firing rate, sorted units, peak histogram, and 3D spike sample histogram
Electrode supportSingle, stereotrode and tetrodeAcquire and online sorting
PlatformWindows® 7, Windows® 10, and Windows® 11

Must use the OmniPlex Windows 10 Migration Guide in order to upgrade to Windows 10.

179 publications, 2013 to 2025. Click a year to expand.

20255 publications▾
202417 publications▾
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202213 publications▾
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  • Haumesser JK, Kühn J, Güttler C, Nguyen DH, Beck MH, Kühn AA, van Riesen C. Fill out the form below to receive a free trial or learn more about access.
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201717 publications▾
  • Anand S, Desai V, Alsmadi N, Kanneganti A, Nguyen DH, Tran M, Patil L, Vasudevan S, Xu C, Hong Y, Cheng J. Asymmetric Sensory-Motor Regeneration of Transected Peripheral Nerves Using Molecular Guidance Cues. Scientific reports. 2017 Oct 30;7(1):14323.
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  • Zhang Y, Gao B, Zheng F, Lu S, Li Y, Xiong Y, Yang Q, Yang Y, Fu P, Xiao F, Wang X. The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities. Frontiers in molecular neuroscience. 2017 Apr 7;10:100.
201611 publications▾
  • Dolzani SD, Baratta MV, Amat J, Agster KL, Saddoris MP, Watkins LR, Maier SF. Activation of a Habenulo–Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat. eNeuro. 2016 Sep 1;3(5):ENEURO-0229.
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  • Giustino TF, Fitzgerald PJ, Maren S. Fear expression suppresses medial prefrontal cortical firing in rats. PloS one. 2016 Oct 24;11(10):e0165256.
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  • Lanzilotto M, Livi A, Maranesi M, Gerbella M, Barz F, Ruther P, Fogassi L, Rizzolatti G, Bonini L. Extending the cortical grasping network: pre-supplementary motor neuron activity during vision and grasping of objects. Cerebral Cortex. 2016 Dec 1;26(12):4435-49.
  • Li JJ, Li YH, Gong HQ, Liang PJ, Zhang PM, Lu QC. The spatiotemporal dynamics of phase synchronization during epileptogenesis in amygdala-Kindling Mice. PloS one. 2016 Apr 21;11(4):e0153897.
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  • Marcinkiewcz CA, Mazzone CM, D'Agostino G, Halladay LR, Hardaway JA, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton GJ. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature. 2016 Sep;537(7618):97.
  • Wang W, Wang X, Chen L, Zhang Y, Xu Z, Liu J, Jiang G, Li J, Zhang X, Wang K, Wang J. The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity. Expert reviews in molecular medicine. 2016 Jan;18.
  • Yang Y, Wang ZH, Jin S, Gao D, Liu N, Chen SP, Zhang S, Liu Q, Liu E, Wang X, Liang X. Opposite monosynaptic scaling of BLP–vCA1 inputs governs hopefulness-and helplessness-modulated spatial learning and memory. Nature communications. 2016 Jul 14;7:11935.
  • Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ. A novel mechanism of memory loss in Alzheimer's disease mice via the degeneration of entorhinal–CA1 synapses. Molecular psychiatry. 2016 Sep 27.
201510 publications▾
  • Aravamuthan BR, Shoykhet M. Long-term increase in coherence between the basal ganglia and motor cortex after asphyxial cardiac arrest and resuscitation in developing rats. Pediatric research. 2015 Oct;78(4):371.
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20145 publications▾
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Headstages

The Digital Headstage Processor works only with digital headstages, sized for acute or chronic research on small and large animals.

Digital Headstages

Digital Headstages

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