| NeuroExplorer® version 5.0 is almost here! By the number of labs who have already requested quotes and/or purchased access to v5.0 since the announcement last month, this is going to be big! If you missed what’s new, here you go: Version 5.0 is a truly significant expansion of functionality over the previous version – seven years in the making! Some of the most significant advances include: - Vastly improved spectral analyses of spike trains and continuous channels including single taper and multi-taper calculations of spectra, six available windowing functions, three preprocessing options, jackknife confidence, the ability to replicate MATLAB® spectral calculations, up to 10 times faster calculation of spectral results and more.
- New analyses of continuous data (LFP) such as perievent rasters, power spectra, coherence, single trial spectrum analysis, and phase analysis using Hilbert Transform.
- New digital filtering options for continuous data including seven new IIR and FIR filters.
- New spike train analyses featuring firing rate versus head direction and single trial rate estimation via adaptive kernels.
- New statistical tests (T-tests, Wilcoxon tests and ANOVA) can compare results across conditions such as implemented via integration with R-script. New statistical tests can be also be added by users by writing R-project.
- Immediate preview of data when a data file is loaded.
- New 64-bit build enabling NeuroExplorer v5.0 to load and analyze multi-gigabyte data files and display hundreds of millions of rows on new data grids.
- Supporting the new .NEX5 data file format that is more flexible than the previous .NEX format such that it allows saving files greater than 2GB in size and saves unlimited metadata for the whole file and for every file variable in JSON format.
- Enhanced ability to save and restore results such that it saves all numerical and graphical results in a series of linked files, and a user can open results files without recalculation, as well as replicate results.
- More efficient processing as computationally demanding analyses are run in parallel using all CPU cores.
- Localized language such that any language can be used in file names, file comments and variable names.
For a quote listing single or three-seat licensing packages, or for upgrades from any prior version of NeuroExplorer, contact info@plexon.com. New Digital Headstages Unveiled at 41st NIC This was the biggest NIC yet with nearly 450 people participating from around the world. Attendees had the first glimpse of Plexon’s PRE-LAUNCH Digital Headstage Processor (DHP) and accompanying Digital Headstages designed for use with Plexon’s flagship OmniPlex® hardware and software. Combined they offer an especially full featured, efficient and economical solution for electrophysiology research laboratories – especially at higher channel counts. The OmniPlex System using the new DHP and digital headstages offers electrical isolation, impedance measurements and digitiziation at 40kHz with phase shift correction for simultaneous sampling – unlike other digital headstage based systems – for up to 256 channel systems. Digital headstages are available in 16, 32 and 64 channels with the 16 and 32 channel headstages weighing 1.0g or less – making them some of the lightest weight digital headstages available today. For more information, contact info@plexon.com. Meet the Workshop Raffle Winner from NIC Due to popular demand, Plexon once again hosted a Workshop Raffle – this time at the NIC. We raffled off a FREE REGISTRATION to the very popular, intense, multi-day, hands-on 2015 Annual Neurophysiology and Behavioral Research Workshop. The winner will receive a full registration valued at $900.00. Earlier this year, the attendees rated the 2014 event an outstanding 9.5/10 – and included the winner from our first Workshop Raffle that took place at Neuroscience 2013. At the close of the conference exhibition today at 10:00 a.m., Central Time, and on behalf of Plexon, KC Kong, Sr. Manager of Sales and Marketing for NeuroNexus, blindly pulled the winning entry from the raffle bin. Plexon is thrilled to congratulate the winner: Sohail Noor from the University of Calgary! Sohail will have the opportunity to take one of the 40 limited seats to join researchers from all over the globe as they descend on Dallas for several days of focused training and exercises presented by renowned researchers and Plexon subject matter experts. We thank all raffle contestants for stopping by and participating. Researchers will have another chance to win during the upcoming 9th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience in Milan, Italy shortly. Next Workshop Raffle at FENS 2014 U-Probes and V-Probes (probes) are exceptionally robust, multi-use linear electrodes. If handled properly, they will provide reliable, consistent recordings for a long time to come. However, it is paramount to establish a proper probe cleaning routine to achieve such dependable longevity. The next few sentences will highlight some of the important aspects of probe cleaning. Any proteins, lipids, blood, or other biological matter must be eliminated immediately after the probe has been removed from the tissue. Otherwise, these substances may dry on the probe surface, covering the sites. This dried layer will serve as an insulator, greatly increasing the impedance during future experiments and resulting in decreased signal quality. Plexon recommends one of two cleaning methods: enzymatic detergents (most recommended) or Nolvasan disinfectant. Should you choose another alternative, ensure that the electrode sites are not physically wiped/rubbed with any material including cloth or cotton swabs as this may have a detrimental effect on impedance. With the enzymatic detergent method, Plexon recommends using either Metrex™ EmPower™ Dual-Enzymatic Detergent or Tergazyme™ from Alconox. In short, you would appropriately dilute the detergent in water between 68-104°F (20-40°C), stir the probe in the solution for ~30 seconds, allow it to soak for 30 minutes, then rinse in purified, distilled water. When using the Nolvasan disinfectant method, place the probe shaft and tip into diluted Nolvasan disinfectant solution for one hour, then rinse by running purified, distilled water over the probe. With either method, finish with air drying and returning the probe to its protective box. If it is not possible to immediately clean the probe after use, it should be submerged in water until it can be thoroughly cleaned. More detailed instructions can be found in the U-Probe Technical Guide or the V-Probe Technical Guide found on the Resources tab of the respective product web pages. Research Spotlight Let us know about your 2014 publication citing Plexon and our equipment and we will send you a thank you award with a mug and a T-shirt! Send notices, address and T-shirt size to publications@plexon.com. All articles listed are alphabetical based on first author within two categories: articles published online in electronic-only journals or ahead of print, and articles published in full print. Recent articles published online in electronic-only journals or ahead of print: - Cichon, Nicole, Michael Denker, Sonja Grün, and Ileana L. Hanganu-Opatz. “Unsupervised classification of neocortical activity patterns in neonatal and pre-juvenile rodents.” Frontiers in Neural Circuits 8 (2014): 50.
- Chew, Kylie S., Tiffany M. Schmidt, Alan C. Rupp, Paulo Kofuji, and Jeffrey M. Trimarchi. “Loss of Gq/11 Genes Does Not Abolish Melanopsin Phototransduction.” PLOS one 9, no. 5 (2014): e98356.
- Dangi, Siddharth, Suraj Gowda, Helene G. Moorman, Amy L. Orsborn, Kelvin So, Maryam Shanechi, and Jose M. Carmena. “Continuous Closed-Loop Decoder Adaptation with a Recursive Maximum Likelihood Algorithm Allows for Rapid Performance Acquisition in Brain Machine Interfaces.” Neural Computation (2014): 1-29.
- Debnath, Shubham, Matthew J. Bauman, Lee E. Fisher, Douglas J. Weber, and Robert A. Gaunt. “Microelectrode array recordings from the ventral roots in chronically implanted cats.” Frontiers in Neurology 5 (2014): 104.
- Ejserholm, F. R. E. D. R. I. K., P. Kohler, M. A. R. C. U. S. Granmo, J. E. N. S. Schouenborg, M. A. R. T. I. N. Bengtsson, and L. A. R. S. Wallman. “Foil Polymer Electrode Array for Intracortical Neural Recordings.” Translational Engineering in Health and Medicine, IEEE Journal of 2 (2014): 1-7.
- Graf, Arnulf BA, and Richard A. Andersen. “Inferring eye position from populations of lateral intraparietal neurons.” eLife 3 (2014).
- Karkhanis, Anushree N., Barbara Heider, Fabian Muñoz Silva, and Ralph M. Siegel. “Spatial Effects of Shifting Prisms on Properties of Posterior Parietal Cortex Neurons.” The Journal of Physiology (2014).
- Keshtkaran, Mohammad Reza, and Zhi Yang. “A fast, robust algorithm for power line interference cancellation in neural recording.” Journal of Neural Engineering 11, no. 2 (2014): 026017.
- Law, Andrew J., Gil Rivlis, and Marc H. Schieber. “Rapid acquisition of novel interface control by small ensembles of arbitrarily selected primary motor cortex neurons.” Journal of Neurophysiology (2014): jn-00373.
- Moll, Christian KE, Edgar Galindo-Leon, Andrew Sharott, Alessandro Gulberti, Carsten Buhmann, Johannes A. Koeppen, Maxine Biermann et al. “Asymmetric pallidal neuronal activity in patients with cervical dystonia.” Frontiers in Systems Neuroscience 8 (2014).
- Nicol, Alister U., Gabriela Sanchez-Andrade, Paloma Collado, Anne Segonds-Pichon, and Keith Maurice FSB Kendrick. “Olfactory bulb encoding during learning under anesthesia.” Frontiers in Behavioral Neuroscience 8 (2014): 193.
- Opris, Ioan, Joshua L. Fuqua, Greg A. Gerhardt, Robert E. Hampson, and Sam A. Deadwyler. “Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation.” Journal of Neuroscience Methods (2014).
- Pan, Zhuo-Hua, Tushar H. Ganjawala, Qi Lu, Elena Ivanova, and Zhifei Zhang. “ChR2 Mutants at L132 and T159 with Improved Operational Light Sensitivity for Vision Restoration.” PLOS one 9, no. 6 (2014): e98924.
- Park, Eunkyoung, Inho Song, Dong Pyo Jang, and In Young Kim. “The effect of low frequency stimulation of the pedunculopontine tegmental nucleus on basal ganglia in a rat model of Parkinson’s disease.” Neuroscience Letters (2014).
- Pisanello, Ferruccio, Leonardo Sileo, Ian A. Oldenburg, Marco Pisanello, Luigi Martiradonna, John A. Assad, Bernardo L. Sabatini, and Massimo De Vittorio. “Multipoint-Emitting Optical Fibers for Spatially Addressable In Vivo Optogenetics.” Neuron (2014).
- Redila, Van, Chantelle Kinzel, Yong Sang Jo, Corey B. Puryear, and Sheri JY Mizumori. “A Role for the Lateral Dorsal Tegmentum in Memory and Decision Neural Circuitry.” Neurobiology of Learning and Memory (2014).
- Schluter, Erik W., Andrew R. Mitz, Joseph F. Cheer, and Bruno B. Averbeck. “Real-Time Dopamine Measurement in Awake Monkeys.” PLOS one 9, no. 6 (2014): e98692.
- Solomon, Selina S., Spencer C. Chen, John W. Morley, and Samuel G. Solomon. “Local and Global Correlations between Neurons in the Middle Temporal Area of Primate Visual Cortex.” Cerebral Cortex (2014): bhu111.
- Stalnaker, Thomas A., Nisha K. Cooch, Michael A. McDannald, Tzu-Lan Liu, Heather Wied, and Geoffrey Schoenbaum. “Orbitofrontal neurons infer the value and identity of predicted outcomes.” Nature Communications 5: 3926 (2014).
- Strait, Caleb E., Tommy C. Blanchard, and Benjamin Y. Hayden. “Reward Value Comparison via Mutual Inhibition in Ventromedial Prefrontal Cortex.” Neuron (2014).
- Thomson, Eric, Jason Lou, Kathryn Sylvester, Annie McDonough, Stefani Tica, and Miguel AL Nicolelis. “Basal forebrain dynamics during a tactile discrimination task.” Journal of Neurophysiology (2014): jn-00040.
- Tziridis, Konstantin, Sabine Korn, Sönke Ahlf, and Holger Schulze. “Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma Induced Hearing Loss and Tinnitus Development.” Neural Plasticity 2014 (2014). Volume 2014 (2014).
- Xiao, Jianbo, Yu-Qiong Niu, Steven Wiesner, and Xin Huang. “Normalization of neuronal responses in cortical area MT across signal strengths and motion directions.” Journal of Neurophysiology (2014): jn-00700.
- Zhang, Die, Andrei Dragomir, Yasemin M. Akay, and Metin Akay. “Nicotine exposure increases the complexity of dopamine neurons in the parainterfascicular nucleus (PIF) subregion of VTA.” Journal of NeuroEngineering and Rehabilitation 11, no. 1 (2014): 103.
- Zheng, Jing-Jing, Shu-Jing Li, Xiao-Di Zhang, Wan-Ying Miao, Dinghong Zhang, Haishan Yao, and Xiang Yu. “Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices.” Nature Neuroscience (2014).
Recent articles published in full print: - Atallah, Hisham E., Andrew D. McCool, Mark W. Howe, and Ann M. Graybiel. “Neurons in the Ventral Striatum Exhibit Cell-Type-Specific Representations of Outcome during Learning.” Neuron 82, no. 5 (2014): 1145-1156.
- Berényi, Antal, Zoltán Somogyvári, Anett J. Nagy, Lisa Roux, John D. Long, Shigeyoshi Fujisawa, Eran Stark, Anthony Leonardo, Timothy D. Harris, and György Buzsáki. “Large-scale, high-density (up to 512 channels) recording of local circuits in behaving animals.” Journal of Neurophysiology 111, no. 5 (2014): 1132-1149.
- Cai, Rui, Bopanna I. Kalappa, Thomas J. Brozoski, Lynne L. Ling, and Donald M. Caspary. “Is GABA neurotransmission enhanced in auditory thalamus relative to inferior colliculus?.” Journal of Neurophysiology 111, no. 2 (2014): 229-238.
- Dick, Paul C., and John R. Gray. “Spatiotemporal stimulus properties modulate responses to trajectory changes in a locust looming-sensitive pathway.” Journal of Neurophysiology 111, no. 9 (2014): 1736-1745.
- Funai, Yusuke, Anthony Edward Pickering, Daisuke Uta, Kiyonobu Nishikawa, Takashi Mori, Akira Asada, Keiji Imoto, and Hidemasa Furue. “Systemic dexmedetomidine augments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending noradrenergic control: An in vivo patch-clamp analysis of analgesic mechanisms.” PAIN 155, no. 3 (2014): 617-628.
- Kuwabara, Masaru, Farshad A. Mansouri, Mark J. Buckley, and Keiji Tanaka. “Cognitive Control Functions of Anterior Cingulate Cortex in Macaque Monkeys Performing a Wisconsin Card Sorting Test Analog.” The Journal of Neuroscience 34, no. 22 (2014): 7531-7547.
- Mian, Matthew K., Sameer A. Sheth, Shaun R. Patel, Konstantinos Spiliopoulos, Emad N. Eskandar, and Ziv M. Williams. “Encoding of rules by neurons in the human dorsolateral prefrontal cortex.” Cerebral Cortex 24, no. 3 (2014): 807-816.
- Ng, Chi-Wing, Bethany Plakke, and Amy Poremba. “Neural correlates of auditory recognition memory in the primate dorsal temporal pole.” Journal of Neurophysiology 111, no. 3 (2014): 455-469.
- Orsborn, Amy L., Helene G. Moorman, Simon A. Overduin, Maryam M. Shanechi, Dragan F. Dimitrov, and Jose M. Carmena. “Closed-Loop Decoder Adaptation Shapes Neural Plasticity for Skillful Neuroprosthetic Control.” Neuron 82, no. 6 (2014): 1380-1393.
- Pezze, Marie, Stephanie McGarrity, Rob Mason, Kevin C. Fone, and Tobias Bast. “Too Little and Too Much: Hypoactivation and Disinhibition of Medial Prefrontal Cortex Cause Attentional Deficits.” The Journal of Neuroscience 34, no. 23 (2014): 7931-7946.
- Roitman, Jamie D., and Amy L. Loriaux. “Nucleus accumbens responses differentiate execution and restraint in reward-directed behavior.” Journal of Neurophysiology 111, no. 2 (2014): 350-360.
- Senn, Verena, Steffen BE Wolff, Cyril Herry, François Grenier, Ingrid Ehrlich, Jan Gründemann, Jonathan P. Fadok, Christian Müller, Johannes J. Letzkus, and Andreas Lüthi. “Long-range connectivity defines behavioral specificity of amygdala neurons.” Neuron 81, no. 2 (2014): 428-437.
- Subramanian, Janani, and Carol L. Colby. “Shape selectivity and remapping in dorsal stream visual area LIP.” Journal of Neurophysiology 111, no. 3 (2014): 613-627.
- Veit, Lena, Konstantin Hartmann, and Andreas Nieder. “Neuronal Correlates of Visual Working Memory in the Corvid Endbrain.” The Journal of Neuroscience 34, no. 23 (2014): 7778-7786.
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